80 GB+ VRAM (datacenter)59 TOOLS FIT THIS TIER

AI tools that run on 80 GB+ datacenter GPUs

Eighty gigabytes and up is datacenter territory — typically rented by the hour rather than owned. This is where you serve 70B+ LLMs at production scale, full fine-tune large models, and run multi-GPU video diffusion pipelines.

YOUR POSITION ON THE VRAM SCALE

TYPICAL GPUS IN THIS TIER //

NVIDIA A100 80GBNVIDIA H100 80GBNVIDIA H200 141GBNVIDIA B200

✓ WHAT YOU CAN RUN

vLLM serving 70B+ models at production throughput
Full fine-tunes of large models
Multi-GPU video diffusion pipelines
Large-context (128k+) LLM workloads
Tensor-parallel inference across multiple GPUs

✕ WHAT STAYS OUT OF REACH

Not applicable — this is the top of the ladder

[ READ THE ASSUMPTIONS ]

VRAM tier ≠ universal guarantee

These are planning envelopes. Model variant, precision, resolution, frame count, context, cache, runtime, and offload can move the same workload across tiers. The guide shows how to validate a real ComfyUI graph before buying hardware.

VRAM decision guide →

Recommended tools for 80 GB+ VRAM (datacenter)

Sorted by best fit for this tier — tools designed around your VRAM budget first, then by our power-user score.

vLLM

High-throughput LLM serving for GPUs.

OPEN SOURCE24–80 GB VRAM

VRAM fit24–80 GB

NVIDIA Cosmos

World-foundation models for physical AI.

OPEN SOURCE24–80 GB VRAM

VRAM fit24–80 GB

HunyuanVideo

13B open-weight cinematic text-to-video.

OPEN SOURCE24–48 GB VRAM

VRAM fit24–48 GB

Magi-1

Autoregressive video diffusion at 24 GB.

OPEN SOURCE24–48 GB VRAM

VRAM fit24–48 GB

Mochi 1

Genmo's 10-B open-weight T2V — the first 'genuinely fluid' OSS video model.

OPEN SOURCE24–60 GB VRAM

VRAM fit24–60 GB

AI-Toolkit (Ostris)

Modern training framework — Flux, SDXL, SD3 LoRAs in YAML.

OPEN SOURCE16–24 GB VRAM

VRAM fit16–24 GB

Modal

Serverless Python for GPU workloads.

FREEMIUM16–80 GB VRAM

VRAM fit16–80 GB

TRELLIS

Microsoft Research's structured 3D representation model.

OPEN SOURCE16–24 GB VRAM

VRAM fit16–24 GB

Pyramid Flow

Memory-efficient T2V via pyramidal flow matching.

OPEN SOURCE16–24 GB VRAM

VRAM fit16–24 GB

Wan 2.2

Open-weight video diffusion from Alibaba.

OPEN SOURCE12–48 GB VRAM

VRAM fit12–48 GB

Kohya_ss

The standard SDXL/Flux LoRA training UI.

OPEN SOURCE12–24 GB VRAM

VRAM fit12–24 GB

3D Gaussian Splatting

The INRIA original — train your own splats.

OPEN SOURCE12–24 GB VRAM

VRAM fit12–24 GB

Hunyuan3D-2

Tencent's open 3D generator — multi-view, PBR, ready-to-use meshes.

OPEN SOURCE12–16 GB VRAM

VRAM fit12–16 GB

LTX-Video

Real-time-ish open video diffusion from Lightricks.

OPEN SOURCE12–16 GB VRAM

VRAM fit12–16 GB

OneTrainer

Modern alternative trainer for SD/SDXL/Flux.

OPEN SOURCE12–24 GB VRAM

VRAM fit12–24 GB

Stable Diffusion 3.5 Large

Stability's MMDiT flagship at 8B params.

OPEN SOURCE12–24 GB VRAM

VRAM fit12–24 GB

SUPIR

Diffusion-based photorealistic upscaler.

OPEN SOURCE12–24 GB VRAM

VRAM fit12–24 GB

CogVideoX 5B

Open-source text-to-video diffusion from THUDM.

OPEN SOURCE12–24 GB VRAM

VRAM fit12–24 GB

FluxGym

Dead-simple Flux LoRA training in a Gradio UI.

OPEN SOURCE12–20 GB VRAM

VRAM fit12–20 GB

Stable Video Diffusion

Image-to-video diffusion — 25 frames, 14 or 25 steps.

OPEN SOURCE12–16 GB VRAM

VRAM fit12–16 GB

ComfyUI-AnimateDiff-Evolved

Animation motion modules for ComfyUI.

OPEN SOURCE10–16 GB VRAM

VRAM fit10–16 GB

FLUX.1 [dev]

12B parameter open-weight diffusion model.

OPEN SOURCE8–24 GB VRAM

VRAM fit8–24 GB

ComfyUI IPAdapter Plus

Reference-image conditioning for ComfyUI.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

Nerfstudio

The open framework for NeRF and Gaussian Splatting research.

OPEN SOURCE8–24 GB VRAM

VRAM fit8–24 GB

Flux.1 Schnell

Black Forest Labs' 4-step distilled Flux.

OPEN SOURCE8–16 GB VRAM

VRAM fit8–16 GB

sd-scripts (Kohya)

The underlying scripts powering Kohya & most LoRA trainers.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

RunPod

On-demand GPU pods for ComfyUI, vLLM, training.

PAID8–80 GB VRAM

VRAM fit8–80 GB

F5-TTS

Zero-shot voice cloning TTS — 15 s of audio is enough.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

InvokeAI

Production-leaning SD studio with canvas & batch.

OPEN SOURCE8–16 GB VRAM

VRAM fit8–16 GB

AnimateDiff

Add motion to any SD checkpoint via a motion module.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

SwarmUI

Power-user front-end that wraps ComfyUI.

OPEN SOURCE8–24 GB VRAM

VRAM fit8–24 GB

MMAudio

Generate synchronized audio for any silent video.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

AudioCraft (MusicGen)

Meta's text-to-music & sound-effect model family.

OPEN SOURCE8–16 GB VRAM

VRAM fit8–16 GB

Instant-NGP

NVIDIA's seconds-to-train hash-grid NeRF.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

Bark

Suno's expressive transformer-based TTS.

OPEN SOURCE8–12 GB VRAM

VRAM fit8–12 GB

ComfyUI

The nodal workflow engine for serious diffusion.

OPEN SOURCE6–16 GB VRAM

VRAM fit6–16 GB

ComfyUI ControlNet Auxiliary

All the ControlNet preprocessors in one node pack.

OPEN SOURCE6–12 GB VRAM

VRAM fit6–12 GB

Stable Diffusion XL

The workhorse open-weight image model.

OPEN SOURCE6–12 GB VRAM

VRAM fit6–12 GB

Text Generation WebUI

The "A1111 for LLMs" — multi-loader local chat UI.

OPEN SOURCE6–24 GB VRAM

VRAM fit6–24 GB

Krita AI Diffusion

Stable Diffusion baked into a real painting app.

OPEN SOURCE6–12 GB VRAM

VRAM fit6–12 GB

TripoSR

Single-image to 3D mesh in under a second on a 4090.

OPEN SOURCE6–8 GB VRAM

VRAM fit6–8 GB

Stable Audio Open

Open-weight text-to-audio — 47-second sound effects and music.

OPEN SOURCE6–8 GB VRAM

VRAM fit6–8 GB

Stable Zero123

Novel-view synthesis — generate any angle from a single image.

OPEN SOURCE6–8 GB VRAM

VRAM fit6–8 GB

Diffusers

Hugging Face's go-to library for every diffusion model.

OPEN SOURCE4–12 GB VRAM

VRAM fit4–12 GB

AUTOMATIC1111 (stable-diffusion-webui)

The original SD power-user webUI.

OPEN SOURCE4–12 GB VRAM

VRAM fit4–12 GB

Topaz Video AI

GPU-accelerated upscaling, frame-interp, denoise.

PAID · $2994–12 GB VRAM

VRAM fit4–12 GB

WhisperX

Whisper + speaker diarisation + word-level timestamps.

OPEN SOURCE4–8 GB VRAM

VRAM fit4–8 GB

XTTS v2 (Coqui)

Multilingual voice cloning in 6 seconds.

OPEN SOURCE4–6 GB VRAM

VRAM fit4–6 GB

Stable Diffusion WebUI Forge

Optimized A1111 fork for low-VRAM cards.

OPEN SOURCE4–8 GB VRAM

VRAM fit4–8 GB

Flowframes

Free RIFE-based frame interpolation.

FREE4–8 GB VRAM

VRAM fit4–8 GB

RVC (Retrieval-based Voice Conversion)

The voice-changer that took over Discord.

OPEN SOURCE4–8 GB VRAM

VRAM fit4–8 GB

Tabby

Self-hosted, GPU-accelerated coding autocompletion.

FREEMIUM · $19/MO4–8 GB VRAM

VRAM fit4–8 GB

Fooocus

Stable Diffusion XL, dialed to one button.

OPEN SOURCE4–8 GB VRAM

VRAM fit4–8 GB

Tortoise TTS

Slow, but the quality is worth the wait.

OPEN SOURCE4–8 GB VRAM

VRAM fit4–8 GB

Transformers

The library every LLM ships against first.

OPEN SOURCE2–24 GB VRAM

VRAM fit2–24 GB

OpenAI Whisper

The reference open-source speech-to-text model.

OPEN SOURCE2–10 GB VRAM

VRAM fit2–10 GB

faster-whisper

Whisper, 4× faster, same accuracy. CTranslate2 backend.

OPEN SOURCE2–6 GB VRAM

VRAM fit2–6 GB

FaceFusion

The most active open face-swap toolkit.

OPEN SOURCE2–8 GB VRAM

VRAM fit2–8 GB

Real-ESRGAN

The default OSS upscaler, still.

OPEN SOURCE2–6 GB VRAM

VRAM fit2–6 GB